PXD054547

PXD054547 is an original dataset announced via ProteomeXchange.

Title	Isoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Suppressing Mitochondrial Fitness
Description	Post operative delirium (POD) is an acute complication characterized by fluctuating attention and confusion which may develop and persist into cognitive decline. POD is most commonly observed in elderly patients, particularly those with preexisting cognitive impairments. Isoflurane, as a widely used volatile anesthetic, is associated with POD. Utilizing the nematode C. elegans, we found that isoflurane enhances protein aggregation and long-lasting decline in protein homeostasis (proteostasis) of adult animals that express neurodegeneration-causing, abnormally long poly-glutamine stretches. Isoflurane-induced proteostasis impairments are dependent on the aging-regulating transcription factors DAF- 16/FOXO and SKN-1/NRF. We also show that reducing the activity of a certain components of the mitophagy mechanism and inducing mitochondrial biogenesis protect worms that exhibit weakened proteostasis, from isoflurane-induced proteotoxicity. Our observations provide novel insights into the mechanism that links isoflurane and POD, and highlight the potential of mitophagy modulators as alleviators of POD in elder patients with preexisting cognitive impairments.
HostingRepository	PRIDE
AnnounceDate	2025-09-13
AnnouncementXML	Submission_2025-09-12_23:18:24.642.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tayir Elami
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-02 14:28:38	ID requested
⏵ 1	2025-09-12 23:18:25	announced

Dataset with its publication pending

submitter keyword: Proteostasis, Proteotoxicity, Mitochondria, Aging,Volatile anesthetics, Delirium, C. elegans

Ehud Cohen
contact affiliation	Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel ג€“ Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel, 9112001.
contact email	ehudc@ekmd.huji.ac.il
lab head
Tayir Elami
contact affiliation	hebrew university of jerusalem
contact email	tayir88@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD054547

PRIDE project URI

• PRIDE
  1. PXD054547
     1. Label: PRIDE project
     2. Name: Isoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Suppressing Mitochondrial Fitness