PXD035656

PXD035656 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	proteomics Reveals the Wolframin-Calcium Axis as a Key Pathogenic Signaling Node in Primary Aldosteronism
Description	Using 4D label-free quantitative proteomics technique, combined with bioinformatics, we generated in-depth proteome and phosphoproteome signaling network maps of aldosterone-producing adenoma and nonfunctioning adrenocortical tumor. We identified wolframin-calcium axis as a key regulatory node in aldosterone synthase activation and aldosterone hypersecretion.
HostingRepository	PRIDE
AnnounceDate	2025-12-26
AnnouncementXML	Submission_2025-12-25_21:06:47.992.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	溢杨
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-01 01:58:06	ID requested
⏵ 1	2025-12-25 21:06:48	announced

Publication List

10.1161/hypertensionaha.122.20515;
Ma L, Yang S, Yang Y, Chen X, Yang J, He Y, Cheng Q, Li J, Kang B, Tang S, Zhang A, Shu X, Li X, Shen H, Jing Y, Song Y, Li Q, Hu J, Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism. Hypertension, 80(5):995-1010(2023) [pubmed]

10.1161/hypertensionaha.122.20515;

Ma L, Yang S, Yang Y, Chen X, Yang J, He Y, Cheng Q, Li J, Kang B, Tang S, Zhang A, Shu X, Li X, Shen H, Jing Y, Song Y, Li Q, Hu J, Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism. Hypertension, 80(5):995-1010(2023) [pubmed]

Keyword List

submitter keyword: Primary Aldosteronism,wolframin,aldosterone,proteome

submitter keyword: Primary Aldosteronism,wolframin,aldosterone,proteome

Contact List

Yang Yi
contact affiliation	the First Affiliated Hospital of Chongqing Medical University
contact email	402535325@qq.com
lab head
溢杨
contact affiliation	Chongqing medical university
contact email	402535325@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD035656
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD035656

PRIDE project URI

Repository Record List

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