PXD030271
PXD030271 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | DNA-PKcs Interacts with Fis1 Induce Mitochondrial Fragmentation During Acute Kidney Injury |
| Description | To analyze the mechanisms underlying DNA-PKcs deletion-mediated renoprotection in an unbiased fashion, we performed proteomic analysis using label free technology to obtain the protein expression profiles in control and DNA-PKcs-deficient mice subjected to septic AKI. 631 proteins were altered by DNA-PKcs deletion during septic AKI (log2FC>1.5), among which 274 proteins reached statistical difference. An expression volcano map of the differentially expressed proteins showed that 153 proteins were upregulated and 121 were downregulated. Kyoto Encyclopedia of Genes and Genome (KEGG) analysis of the 274 proteins showed that the apoptosis pathway was the most downregulated upon DNA-PKcs deletion during septic AKI. Gene Ontology (GO) Cellular Component Enrichment Analysis demonstrated that 101 of the 274 proteins were enriched to mitochondria |
| HostingRepository | iProX |
| AnnounceDate | 2021-12-08 |
| AnnouncementXML | Submission_2023-12-21_22:08:48.683.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xing Chang |
| SpeciesList | scientific name: Acyrthosiphon pisum; NCBI TaxID: 7029; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-12-08 18:07:26 | ID requested | |
| 1 | 2021-12-08 18:07:45 | announced | |
| ⏵ 2 | 2023-12-21 22:08:49 | announced | 2023-12-22: Update publication information. |
Publication List
| Wang S, Zhu H, Li R, Mui D, Toan S, Chang X, Zhou H, DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. Sci Signal, 15(725):eabh1121(2022) [pubmed] |
Keyword List
| submitter keyword: DNA-PKcs, Acute renal injury, mitochondria, apoptosis, Kyoto Encyclopedia of Genes and Genome |
Contact List
| Hao Zhou | |
|---|---|
| contact affiliation | University of Wyoming College of Health Sciences |
| contact email | zhouhao301@outlook.com |
| lab head | |
| Xing Chang | |
| contact affiliation | Shandong University of traditional Chinese Medicine |
| contact email | xingchang_tcm@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
