PXD029188

PXD029188 is an original dataset announced via ProteomeXchange.

Title	Tear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses
Description	Contact lens-related ocular surface complications occur more often in teenagers and young adults. The purpose of this study was to determine changes in tear proteome of young patients wearing glasses (GL), orthokeratology lenses (OK), and soft contact lenses (SCL). Twenty-two young patients (10-26 years of age) who were established (> 3 years) GL (n=10), OK (n=6), and SCL (n=6) wearers were recruited. Tears were collected via Schirmer strips. Proteomic data were collected using a data-independent acquisition-parallel accumulation serial fragmentation (diaPASEF) workflow. Tear proteome composition and abundance were compared across different correction groups and between the children (age <18 years) and young adults (age 18 years) GL wearers. We identified 3406 protein groups in tears. Among proteins identified in 80% of tear samples, 8 proteins were upregulated, and 11 proteins were down-regulated in the SCL group compared to the OK group. Eighty-two proteins were differentially expressed in children and young adults GL wearers, among which 67 proteins were upregulated, and 15 proteins were downregulated in children. These 82 proteins were involved in 1 inflammation, 9 immune, and 1 glycoprotein metabolic biological processes. As teenagers and young adults have the highest risk of developing contact lens-related complications, this work highlights the importance of understanding ocular responses to contact lens wear across different ages.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:40:59.985.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guoting Qin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-18 01:56:12	ID requested
1	2022-11-07 11:35:58	announced
2	2023-11-14 08:52:41	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:41:00	announced	2024-10-22: Updated project metadata.

10.1016/J.JPROT.2022.104738;

submitter keyword: Human, soft contact lens, Schirmer strip, orthokeratology, tears

Guoting Qin
contact affiliation	University of Houston, Houston, TX 77204, USA
contact email	gqin@central.uh.edu
lab head
Guoting Qin
contact affiliation	University of Houston
contact email	gqin@central.uh.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD029188

PRIDE project URI

• PRIDE
  1. PXD029188
     1. Label: PRIDE project
     2. Name: Tear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses