PXD026832

PXD026832 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of humidifier disinfectant-associated lung injury
Description	Humidifier disinfectant-associated lung injury (HDLI) is affected by long-term inhalational exposure to toxic polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) and characterized by the rapid progression of respiratory failure with lung fibrosis and frequent air leak syndrome with high mortality. However, the underlying mechanism of the disease is not yet understood. This is the first multi-omics (transcriptomics and proteomics) and network study using human lung tissue and identified a potential MMP2-mediated different mechanism between child and adult in HDLI: adult-specific accelerated TGFβ/SMAD signaling pathway under the pre-exposure to environmental toxic materials, whereas child-specific integrin-mediated signaling pathway.
HostingRepository	PRIDE
AnnounceDate	2025-09-12
AnnouncementXML	Submission_2025-09-12_01:51:16.764.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jeonghun Yeom
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-21 03:04:09	ID requested
⏵ 1	2025-09-12 01:51:17	announced

Kim JH, Kim K, Yeom J, Lee E, Kang MJ, Lee SH, Kim K, Lee SY, Hong SB, Oh DK, Lee K, Choi SJ, Yang MJ, Kim J, Hong SJ, Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury. Clin Transl Med, 11(11):e562(2021) [pubmed]

10.1002/ctm2.562;

submitter keyword: Humidifier disinfectant-associated lung injury (HDLI), formalin-fixed paraffin-embedded (FFPE) tissues, polyhexamethylene guanidine (PHMG)

Soo-Jong Hong
contact affiliation	Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
contact email	sjhong@amc.seoul.kr
lab head
Jeonghun Yeom
contact affiliation	prometabio co., ltd.
contact email	nature8309@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD026832

PRIDE project URI

• PRIDE
  1. PXD026832
     1. Label: PRIDE project
     2. Name: Proteome analysis of humidifier disinfectant-associated lung injury