PXD012153

PXD012153 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Coxsackievirus B persistence modifies the proteome of pancreatic ductal cells in a virus-strain-specific manner
Description	In human cells, the group B Coxsackieviruses can establish persistent infections that have been linked to chronic diseases including type 1 diabetes. Still, only little is known about the changes induced by persistent Coxsackievirus B infection in human pancreas. We have established persistent Coxsackievirus B1 infections in human pancreatic duct cell line using two different virus strains, and studied the consequences of these infections on intracellular protein expression using mass spectrometry-based proteomics. Persistent Coxsackievirus B1 infections caused broad changes in protein expression, for example changes in mitochondrial morphology and energy metabolism and in proteins associated with differentiation and survival of pancreatic beta-cells. Strikingly, many of these changes differed between the virus strains, including extensive shut down of antiviral immune responses by one of the viruses. Our results provide novel information about the changes induced by persistent Coxsackievirus B infection in human pancreas and about the potential heterogeneity in the outcomes of the infections.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:51:35.040.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Niina Lietzen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-21 04:11:35	ID requested
1	2019-08-06 02:43:41	announced
⏵ 2	2024-10-22 04:51:35	announced	2024-10-22: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

curator keyword: Biomedical
submitter keyword: pancreas, proteomics,enterovirus, persistent infection

curator keyword: Biomedical

submitter keyword: pancreas, proteomics,enterovirus, persistent infection

Contact List

Riitta Lahesmaa
contact affiliation	Turku Centre for Biotechnology University of Turku and Åbo Akademi University Finland
contact email	riitta.lahesmaa@utu.fi
lab head
Niina Lietzen
contact affiliation	University of Turku
contact email	niina.lietzen@utu.fi
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD012153
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD012153

PRIDE project URI

Repository Record List

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