Plant cells are enclosed by a semi-rigid cell wall with a complex biochemical composition and architecture. The poorly understood remodeling of the cell wall is crucial for controlling growth and development, as well as for regulating abiotic and biotic stress responses. Cell wall remodeling upon disruption of cell wall integrity by inhibition of cellulose biosynthesis (CBI) depends on the receptor kinase STRUBBELIG (SUB) and its binding partner QUIRKY (QKY). Here, we identify NON-RACE SPECIFIC DISEASE RESISTANCE/HIN1 HAIRPIN-INDUCED-LIKE protein 2 (NHL2) and NHL3 as additional factors involved in the SUB-dependent CBI response. Collectively, our data indicate that NHL3 maintains SUB at the plasma membrane by physically interacting with SUB. SUB signaling is attenuated by receptor-mediated endocytosis initiated by release of first the SUB/NHL3 and later the SUB/QKY interaction. Our results further suggest a diverse set of biochemically and functionally distinct SUB complexes involved in regulating cell wall integrity and development.