Histone acetylation, a fundamental epigenetic mechanism that controls gene activity, is essential for the developmental plasticity and virulence of the parasite Toxoplasma gondii. However, how this parasite organizes and deploys its acetyltransferase machinery has remained unclear. We show that T. gondii rewired this process using a plant-like system built around the acetyltransferase TgGCN5b, which differs from the typical SAGA complex found in other eukaryotes. We complete our interactome analysis by characterizing TgGCN5b interactome in PHD1 KD or AP2XI-2 and AP2XII-1 KD parasites, TgGCN5b interactome from simple and double purifications, and TgGNAT2 interactome.