This project includes 6 experimental groups (Group A-G) of exosomes derived from the human acute myeloid leukemia cell line KG-1a, KG-1, Kasumi-1, THP-1, U937, and HEL cells, resulting in a total of 6 Thermo RAW mass spectrometry files. LC-MS analysis was then used to identify and characterize proteins carried by leukemia cell-derived exosomes. **File Description** The uploaded "SEARCH.zip" file contains all corresponding protein, peptide, and PSM identification results for this proteomics project. All .raw files have been successfully associated with this "SEARCH.zip" file in the backend. The "null" display in the "Related File" column is a known frontend bug of the iProX platform and does not affect the validity of the data submission.