In the previous works, we have identified a microprotein PoxTMA7 positively regulate cellulase and xylanase production in Penicillium. oxalicum. Intergrated Ribo-seq and RNA-seq analysis demonstrated that the microprotein PoxTMA7 reprogram translation landscape in P. oxalicum. Particularly, the deletion of the gene PoxTMA7 leads to the reduced translation efficiency (TE) of key cellulase and xylanase genes. To evaluated the effects of PoxTMA7 on the abundance of cellulase, xylanase and other extracellular proteins in P. oxalicum. We performed comparative DIA-proteomics of cultures from P. oxalicum strains dataPoxTMA7 and WT.