The global prevalence of multidrug-resistant bacteria represents an urgent public health challenge, emphasising the critical need for novel antimicrobial agents. Multidrug-resistant (MDR) Acinetobacter baumannii, a nosocomial pathogen of critical global concern owing to its capacity to acquire and disseminate antimicrobial resistance, was employed as a bacterial model to investigate the antimicrobial potential of natural products derived from Caesalpinia pulcherrima (L.) Sw. (Fabaceae).