This project investigated hepatic proteomic profiles associated with tissue-specific fat deposition in chickens. Chickens were grouped according to the intramuscular fat content of the breast muscle and abdominal fat content. Liver samples from chickens with high or low intramuscular fat deposition and high or low abdominal fat deposition were analyzed using quantitative proteomics. Raw data of low intramuscular fat group includes 91138-8, 91138-9, 91138-11, 91138-12; high intramuscular fat group includes 91138-4, 91138-5, 91138-7, 91138-15; low abdominal fat group includes 91138-2, 91138-6, 91138-10, 91138-15; high abdominal fat group includes 91138-1, 91138-3, 91138-13, 91138-14.