This study presents an integrated metabolomics and proteomics analysis of human adipose tissue from two groups (A and B, n=7 each). Untargeted metabolomics (LC‑MS/MS) identified 2,305 metabolites, with 145 significantly different between groups (73 up, 72 down in Group A). The metabolomics data are available under MTBLS14456 in MetaboLights. Complementary proteomics analysis on the same samples quantified protein expression differences using label‑free LC‑MS/MS. The combined multi‑omics dataset reveals molecular signatures differentiating the two groups and provides a valuable resource for understanding adipose tissue metabolism