Exploratory biomarker studies of high-grade serous ovarian carcinoma (HGSOC) remain challenging in gynaecological oncology due to the lack of reliable, non-invasive diagnostic approaches. Recent evidence suggests that the cervical microenvironment may reflect distal ovarian malignancy through a "field effect," manifesting as epigenetic and proteomic alterations. This study investigates the potential of cervicovaginal sampling (CVS) for HGSOC detection by profiling proteins involved in epigenetic regulation.