⮝ Full datasets listing
PXD076549-1
PXD076549 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Epitranscriptomic m6A reader HNRNPC amplifies oxidative stress–autophagy dysregulation and aggravates placental dysfunction in preeclampsia |
| Description | We integrated transcriptomic, proteomic, and untargeted metabolomic profiling of placentas from PE patients and normotensive controls, followed by validation in an independent clinical cohort. Mechanistic roles were interrogated using hypoxia-treated HTR-8/SVneo trophoblasts and an L-NAME–induced PE-like mouse model. Autophagy dynamics were assessed using dual-fluorescent autophagic flux reporters, transmission electron microscopy, and molecular markers. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-03 |
| AnnouncementXML | Submission_2026-04-02_23:07:14.654.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qiying Zhu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-02 23:06:53 | ID requested | |
| ⏵ 1 | 2026-04-02 23:07:15 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: preeclampsia placental Proteomic |
Contact List
| Qiying Zhu | |
|---|---|
| contact affiliation | The First Affiliated Hospital of Xinjiang Medical University |
| contact email | zhuqiying123451@163.com |
| lab head | |
| Qiying Zhu | |
| contact affiliation | The First Affiliated Hospital of Xinjiang Medical University |
| contact email | zhuqiying123451@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
