PXD076348-1

PXD076348 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of bone marrow aspirate (BMA) samples collected pre-VD-CAG induction and post-induction VD-CAG-treated non-M3 AML
Description	Proteomic profiling was performed by Novogene (Beijing, China), using data-independent acquisition (DIA) proteomics on paired bone marrow aspirate samples from 5 non-M3 AML patients before and after VD-CAG treatment. All patients achieved composite complete response (CRc) after 1 cycle of VD-CAG induction. Protein extraction, quantification, enzymatic digestion with trypsin (allowing up to 2 missed cleavage sites), desalting, and fractionation were conducted following standard protocols to ensure data quality at each step. Peptides were separated using nano-LC on a Vanquish Neo system and analyzed on an Orbitrap Astral high-resolution mass spectrometer, which features a quadrupole for precursor ion selection, an Orbitrap analyzer for high-dynamic-range HRAM spectra, and an Astral analyzer for high-sensitivity, up to 200 Hz HRAM spectral acquisition.
HostingRepository	iProX
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-31_01:06:18.390.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuping Gong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-31 01:06:03	ID requested
⏵ 1	2026-03-31 01:06:19	announced

Dataset with its publication pending

submitter keyword: Proteomics

VD-CAG induction

non-M3 AML

Yuping Gong
contact affiliation	West China Hospital
contact email	gong2025@wchscu.edu.cn
lab head
Yuping Gong
contact affiliation	West China Hospital
contact email	gong2025@wchscu.edu.cn
dataset submitter

iProX dataset URI