Twenty-four-week-old db/db spontaneous type 2 diabetic mice (n=9) and db/m non-diabetic mice (n=9) were selected.Based on the behavioral test (water maze) results, the mice were divided into two groups: the DB group (cognitive-behavioral abnormality group) and the M group (cognitive-behavioral normal group). High-throughput mass spectrometry techniques, including tandem mass tag (TMT)-labeled proteomics.