live-cell ITDR-MS-CETSA experimental set comprised of 4 thermal challenge temperatures (37 °C, 50 °C, 55 °C, 60 °C), each spanning a 10-point drug concentration range. Each thermal set comprises 20 High_pH fractions, analysed by MS consecutively. The DMSO reference channel is labelled with TMT131 The highest drug dose is labelled with TMT126