Breast cancer (BC) is the prevailing malignancy among women, exhibiting a discernible escalation in incidence within our nation, hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) breast cancer is the most common subtype. In this study, we aimed to search for a non-invasive, specific, blood-based biomarker for the early detection of luminal A breast cancer through proteomic studies.