K-GG ubiquitin profiling of SK-MEL-2 and UO-31 cells treated with the selective USP9X inhibitor WEHI-092 at 10 µM for 30 min, 6 h, and 24 h (and DMSO-treated control). This dataset is the matched global quantitative proteomics data. Sample IDs: #1-5 Control 30 min UO-31 #6-10 WEHI-092 30 min UO-31 #11-15 Control 360 min UO-31 #16-20 WEHI-092 360 min UO-31 #21-25 Control 24 h UO-31 #26-30 WEHI-092 24 h UO-31 #31-35 Control 30 min SK-MEL-2 #36-40 WEHI-092 30 min SK-MEL-2 #41-45 Control 360 min SK-MEL-2 #46-50 WEHI-092 360 min SK-MEL-2 #51-55 Control 24 h SK-MEL-2 #56-60 WEHI-092 24 h SK-MEL-2