This dataset contains mass spectrometry-based proteomic data generated from pleural tissuesamples.Proteins were extracted, digested, and labeled using TMT isobaric labeling for quantitative analysis. Samples were analyzed using LC–MS/MS to profile the global proteome.The dataset includes raw mass spectrometry files, processed search results, and experimentalmetadata. Multiple biological and technical replicates were included for each condition toensure reproducibility. This dataset supports quantitative protein profiling and can be used for downstream analyses of pleural tissue proteomes.