Tauopathies are a group of neurodegenerative diseases characterised by the abnormal accumulation of tau protein within neural and glial cells. The molecular mechanisms of tauopathies remain poorly understood. To identify proteins whose abundance is altered by the disease group, we performed a proteomic analysis of brain homogenate from patients with three tauopathy-related diseases: corticobasal degeneration, progressive supranuclear palsy and Alzheimer's disease.