PXD072559 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | AI-powered Deep Visual Proteomics unmasks critical molecular transitions in pancreatic cancer precursors |
| Description | Pancreatic ductal adenocarcinoma (PDAC) evolves through precursors, yet the protein programs that govern early progression remain poorly defined. We applied Deep Visual Proteomics - computational pathology, laser microdissection, and mass spectrometry (MS) - to profile normal ducts, acinar-to-ductal metaplasia (ADM), low- and high-grade pancreatic intraepithelial neoplasia (PanIN), and invasive carcinoma from organ donors and patients with PDAC. Quantifying 9,181 proteins from ~100 cells per region, we uncovered a molecular field effect in histologically normal ducts and showed that low-grade PanINs diverge by cancer context. Four programs - stress adaptation, immune engagement, metabolic reprogramming, and mitochondrial remodeling - emerged early and intensified with progression. High-grade PanINs exhibited distinct metabolic signatures preceding invasion. Notably, mass spectrometry detected KRAS hotspot mutant peptides directly within PanINs and ADM, providing protein-level evidence of oncogenic alteration in precursor lesions. These findings demonstrate that molecular reprogramming precedes histological transformation, creating opportunities for earlier detection of this lethal cancer. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-01 |
| AnnouncementXML | Submission_2026-03-31_23:31:16.224.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lisa Schweizer |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-31 09:12:34 | ID requested | |
| ⏵ 1 | 2026-03-31 23:31:16 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Deep Visual Proteomics, laser microdissection, pathology foundation models, mass spectrometry, artificial intelligence, precursor, spatial, tumor, Pancreatic ductal adenocarcinoma |
Contact List
| Andreas Mund |
|---|
| contact affiliation | OmicVision Biosciences ApS |
| contact email | amund@omicvision.com |
| lab head | |
| Lisa Schweizer |
|---|
| contact affiliation | OmicVision Biosciences ApS |
| contact email | admin@omicvision.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD072559 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072559
- Label: PRIDE project
- Name: AI-powered Deep Visual Proteomics unmasks critical molecular transitions in pancreatic cancer precursors
