Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from Crocus sativus L. (Saffron), and have demonstrated various bioactivities including anti-tumor, anti-inflammation, anti-oxidation, anti-ischemia, anti-aging, and neuroprotection.