PXD070931 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis |
| Description | Given the hypothalamus central role in energy homeostasis and its emerging vulnerability in ALS, this study aimed to determine whether hypothalamic mitochondrial dysfunction may contribute to and potentially drive disease-related metabolic disturbances, thereby representing a potential therapeutic target. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-05_16:27:43.825.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Viviana Greco |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | (R)-5-oxo-1; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-18 21:46:29 | ID requested | |
| ⏵ 1 | 2026-04-05 16:27:44 | announced | |
Publication List
| Scaricamazza S, Nesci V, Fenili G, Tiberi M, Percio A, Rosina M, Salvatori I, Riggio F, Candelise N, Pieroni L, Greco V, Chiurchi, รน V, Ferri A, Valle C, The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis. Mol Metab, 107():102360(2026) [pubmed] |
| 10.1016/j.molmet.2026.102360; |
Keyword List
| submitter keyword: proteomics,mitochondria, ALS |
Contact List
| Viviana Greco |
|---|
| contact affiliation | Catholic University of the Sacred Heart |
| contact email | viviana.greco@unicatt.it |
| lab head | |
| Viviana Greco |
|---|
| contact affiliation | Catholic University of the sacred heart |
| contact email | viviana.greco@unicatt.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070931 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070931
- Label: PRIDE project
- Name: The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis
