⮝ Full datasets listing
PXD070139
PXD070139 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CRISPR-free RNA Base Editing Mediated PTC-readthrough Restores Hearing in Mice with Otof Nonsense Mutation |
| Description | We then deliver the ‘RESTART v3’ system, which is a CRISPR-free RNA base editor for nonsense mutation suppression, into the cochlea of the mice. We achieve physiological otoferlin expression, the edited premature termination codon is reverse-mutated to the original amino acid. We observe significant hearing restoration and enhancement of the behavioral auditory startle reflex. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-31 |
| AnnouncementXML | Submission_2025-10-31_00:54:21.265.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hanxiao Sun |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-31 00:53:17 | ID requested | |
| ⏵ 1 | 2025-10-31 00:54:21 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: OTOF, RNA editing |
Contact List
| Chengqi Yi | |
|---|---|
| contact affiliation | Peking University |
| contact email | chengqi.yi@pku.edu.cn |
| lab head | |
| Hanxiao Sun | |
| contact affiliation | Peking University |
| contact email | hanxiao.sun@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
