PXD070000

PXD070000 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Midbrain extracellular matrix and microglia are associated with cognition in aging mice
Description	The present study combines high resolution imaging, quantitative tissue proteomics, novel goal directed behaviors, and genetic inductions of microglial depletion and accelerated aging to link microglia, synapse, and ECM status across the mesolimbic dopamine system with cognitive aging outcomes.
HostingRepository	MassIVE
AnnounceDate	2025-10-29
AnnouncementXML	Submission_2025-10-29_12:26:33.696.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adarsh Mayank
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-28 18:57:41	ID requested
⏵ 1	2025-10-29 12:26:34	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: cognitive decline, synapses, Extracellular Matrix Aging Microglia Basal Ganglia, DatasetType:Proteomics

submitter keyword: cognitive decline, synapses, Extracellular Matrix Aging Microglia Basal Ganglia, DatasetType:Proteomics

Contact List

Lindsay De Biase
contact affiliation	UCLA
contact email	lmdebiase@mednet.ucla.edu
lab head
Adarsh Mayank
contact affiliation	UCLA
contact email	adarshmayank@gmail.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096508/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096508/