Here we employ LC-MS-based bottom-up proteomics to address the metabolic responses of the A. caudatus root and leaves to moderate Zn stress. Thereby, we aimed identification of the Zn-responsive proteins in the roots, young and mature leaves of the A. caudatus plants exposed to Zn stress for seven days, as well as their comprehensive discussion in the context of the Zn2+-induced adaptive metabolic shifts discovered in these organs earlier.