Revealing Cerebrospinal Fluid Biomarkers in Parkinson's Disease Dementia Based on iTRAQ Proteomics Research," for consideration for publication in frontiers in neuroscience. This study identifies and functionally validates Insulin-like Growth Factor Binding Protein 3 (IGFBP3) as a novel cerebrospinal fluid (CSF) biomarker candidate for Parkinson's disease dementia (PDD), demonstrating its neuroprotective role via the PI3K/Akt/GSK3β signaling pathway.