PXD068137 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | BOLL-containing Aggregates Mediate the Translational Regulation During Human Oogenesis |
| Description | Humanoocyte meiosis utilizes a specialized translational control strategy tocoordinate meiotic progression, mediated through dynamic regulation of mRNAstores. While germ cell-specific RNA-binding proteins (RBPs) are known toorchestrate this post-transcriptional program, the mechanistic basis ofRBP-mediated cell fate specification remains elusive. Here, we demonstrate that 000000000000000BOLL, a Deleted in Azoospermia (DAZ) family protein, forms protein aggregatesduring meiotic prophase to drive translational reprogramming in humanoogenesis. We determined that BOLL enhance translation efficiency of cell cycleregulators, as demonstrated by integrative translatome-transcriptome analysiscombined with RNA immunoprecipitation sequencing. We also revealed the functionalinteraction network of BOLL with coretranslation machinery components through its conserved DAZ containing domain. Crucially, we identified the SDS-resistantprotein aggregates as BOLL structural signature in human oocyte-like cells,demonstrated by semi-denaturing electrophoretic analysis. These finding delineate a protein aggregate-mediatedregulatory paradigm where BOLL aggregates exert spatiotemporal control overcell cycle related genes during the meiotic prophase of human oogenesis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-03 |
| AnnouncementXML | Submission_2026-04-03_00:15:50.351.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ying Li |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-05 20:18:30 | ID requested | |
| ⏵ 1 | 2026-04-03 00:15:50 | announced | |
Publication List
Keyword List
| submitter keyword: translational regulation, protein aggregate,human BOLL protein, oogenesis |
Contact List
| Kehkooi Kee |
|---|
| contact affiliation | The State Key Laboratory for Complex, Severe, and Rare Diseases; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. |
| contact email | kkee@tsinghua.edu.cn |
| lab head | |
| Ying Li |
|---|
| contact affiliation | Fuzhou University |
| contact email | liying.2018@tsinghua.org.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD068137 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068137
- Label: PRIDE project
- Name: BOLL-containing Aggregates Mediate the Translational Regulation During Human Oogenesis
