To elucidate the molecular mechanisms underlying Corylin-mediated delay of aging, we employed an integrated multi-omics approach—comprising proteome, phosphoproteome, and lysine acetylome analyses—using tissue samples from quadriceps, kidney, and liver collected from both male and female C57BL/6J mice. Comparative profiling across three groups—young, aged, and aged mice treated with Corylin—enabled a systematic characterization of Corylin-induced molecular alterations associated with aging.