PXD066552

PXD066552 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	MesoMap: Mesoscale proximity labeling of chromatin for small molecule mechanism of action
Description	Mesoscale proximity labeling of chromatin is used to understand the impact that inhibitors have on chromatin structure and dynamics. We use uMap proximity labeling, distributed throughout chromatin to study how HDAC inhibition alters interactions. We then apply this approach to de-orphan a high throughput screening hit SR1815. We show that SR1815 is a kinase inhibitor that hits CLK proteins and alters RNA splicing.
HostingRepository	MassIVE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-22_13:12:28.187.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ciaran Seath
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Phospho
Instrument	timsTOF Pro 2; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-24 09:54:59	ID requested
⏵ 1	2025-09-22 13:12:28	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: chromatin, proximity labeling, DatasetType:Proteomics

submitter keyword: chromatin, proximity labeling, DatasetType:Proteomics

Contact List

Ciaran Seath
contact affiliation	University of Florida
contact email	cseath@ufl.edu
lab head
Ciaran Seath
contact affiliation	UF-Scripps
contact email	cseath@ufl.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098636/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098636/