Adult hippocampal neurogenesis is involved in key cognitive phenomena, such as memory and learning, mood regulation, stress and anxiety. In postmortem human patients, adult neurogenesis has been shown to decrease in correlation with Alzheimer’s disease and mild cognitive decline. Thus, therapies aiming to restore neurogenesis and neural differentiation in the hippocampus are currently emerging. Electrical stimulation has been shown to modulate the proliferation and differentiation of neural progenitor cells (NPCs). Although stimulation therapies such as deep brain stimulation (DBS) have been widely used in the clinic, their invasiveness hinders regenerative medicine applications. DBS via temporally interfering (TI) electric fields has emerged as a promising strategy for non-invasive deep brain stimulation (Grossman et al., 2017). We previously demonstrated via immunohistochemistry that TI stimulation at the theta frequency for 8 days, 1h/day, increases differentiation (doublecortin) and proliferation (ki67) in the right dentate gyrus of 6-7 months old APPN-L-GF mouse models. Here, we investigate potential mechanisms of such neurogenic effect via bulk proteomics in the ipsilateral dentate gyrus of TI-stimulated and sham mice. We report an increased expression of chemical synaptic transmission pathways, mRNA metabolism and the MAPK/ERK cascade (among others) in the TI-stimulated mice compared to sham.