tripartite motif-containing protein 25 (TRIM25), ubiquitin protein ligase 5 (UBR5), Myc-binding protein 2 (MYCBP2), membrane-associated RING finger protein 5 (MARCHF5), and tripartite motif-containing protein 50 (TRIM50) are involved in DDO3602-mediated degradation of PARP1.