PXD065988

PXD065988 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Exploration of the Recently Re-classified Forest Cobra Naja Species and the Potential Cytotoxic Activity in Cancer Cell Lines
Description	African forest cobra venom is a rich source of bioactive compounds such as cytotoxins, which cause tissue necrosis and descending paralysis. However, the venom has also been identified as a potential source of therapeutic agents, including anticancer agents. In this study, we evaluate the anticancer effects of the N. melanoleuca, N. subfulva, and N. savannula venoms and their fractions against the selected cell lines. The 3FTxs and PLA2s, which are the most abundant protein families in the venoms, are predominantly responsible for the cytotoxic effects. In conclusion, this research study highlights the important role of forest cobra venoms as potential resources that researchers can further exploit to investigate the molecules responsible for the anticancer effect and investigate their mechanisms of action.
HostingRepository	jPOST
AnnounceDate	2025-07-10
AnnouncementXML	Submission_2025-07-10_00:56:28.964.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Phetolo Motsa
SpeciesList	scientific name: cellular organisms; NCBI TaxID: 131567;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-10 00:56:26	ID requested
⏵ 1	2025-07-10 00:56:29	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Anticancer potential, cancer, cobra venoms, cytotoxins, selectivity, venomics

submitter keyword: Anticancer potential, cancer, cobra venoms, cytotoxins, selectivity, venomics

Contact List

Phetolo Motsa
lab head
Phetolo Motsa
contact affiliation	University of Johannesbug
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003924/