This study investigates the proteomic response of Brassica species to lead (Pb) stress. The proteomic profiles of Brassica juncea and Brassica napus were compared under both Pb-exposed and control conditions to identify key proteins associated with Pb tolerance mechanisms. Additionally, the extent of Pb toxicity in these species was assessed. The findings provide valuable insights into the molecular basis of Pb stress response and offer potential strategies for enhancing Pb tolerance in crop plants.