PXD064761

PXD064761 is an original dataset announced via ProteomeXchange.

Title	The EVI5 oncogene drives tumor immune escape by regulating PD-L1 in Lung Adenocarcinoma
Description	Ecotropic viral integration site 5 (EVI5), a member of the Tre-2/Bub2/Cdc16 (TBC) domain-containing protein family, has been implicated in the initiation of various cancers. However, its precise role in lung adenocarcinoma (LUAD) remains unclear. This study investigated the pro-tumoral role of EVI5 in LUAD, focusing on its regulation of PD-L1, a key molecule involved in tumor immune evasion. In the present study, EVI5 was significantly overexpressed in LUAD tissues compared to adjacent normal tissues. In vitro experiments demonstrated that EVI5 knockout suppressed tumor immune escape. Notably, EVI5 overexpression promotes immune evasion by interacting with Rab11. Mechanistically, EVI5 was found to regulate downstream signaling pathways through Rab11-mediated activation of PD-L1 in LUAD cells. These findings suggest that EVI5 plays a crucial role in modulating immune escape, and may influence the efficacy of immunotherapeutic agents.
HostingRepository	iProX
AnnounceDate	2025-06-07
AnnouncementXML	Submission_2025-06-09_00:34:31.427.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tingting Cai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-09 00:33:56	ID requested
⏵ 1	2025-06-09 00:34:31	announced

Dataset with its publication pending

submitter keyword: EVI5, Rab11, PD-L1, LUAD, immunotherapy

Tingting Cai
contact affiliation	The Third Affiliated Hospital of Soochow University
contact email	18896733697@163.com
lab head
Tingting Cai
contact affiliation	The Third Affiliated Hospital of Soochow University
contact email	18896733697@163.com
dataset submitter

iProX dataset URI