In this study, we investigated how EGFR activation via EGF treatment reprograms metabolic pathways in triple-negative breast cancer (TNBC) cells by modulating autophagic secretion. Proteomic profiling was performed on isolated autophagosomes from EGF-treated MDA-MB-231 cells to identify outermembrane-associated proteins. These data provide insights into how secretory autophagy contributes to tumor metabolic remodeling.