PXD064463

PXD064463 is an original dataset announced via ProteomeXchange.

Title	Histone post-translational modifications of Leishmania braziliensis
Description	Eukaryotic cells have natural resources to maintain their biological activities for the organism. Epigenetics is one of these mechanisms, which plays a fundamental role in the regulation of gene expression, cell cycle progression, DNA repair, etc. Epigenetic control of gene expression occurs when chemical groups are added to some histone amino acids, resulting in dynamic changes in the structure and organization of chromatin, besides being recruiters of protein complexes. Recently, our group described the global map of post-translational modifications of histone (hPTMs) of Trypanosoma cruzi, showing that, despite being unicellular eukaryotes with a characteristic post-transcriptional gene expression, their chromatin is complex with an abundant and variable number of hPTMs. In this work, we describe, the first comprehensive and high-confidence global map, of the hPTMs of Leishmania braziliensis, the etiologic agent of leishmaniasis, distributed in all canonical and some variants.
HostingRepository	PRIDE
AnnounceDate	2025-09-26
AnnouncementXML	Submission_2025-09-26_07:11:34.681.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD064463
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Rafael de Almeida
SpeciesList	scientific name: Leishmania braziliensis MHOM/BR/75/M2904; NCBI TaxID: 420245;
ModificationList	monomethylated residue; ubiquitinylated lysine; crotonylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; formylated residue; dimethylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-30 17:29:54	ID requested
⏵ 1	2025-09-26 07:11:35	announced

10.6019/PXD064463;

submitter keyword: Leishmania braziliensis, histones, PTM, LC-MS/MS

Lyris Martins
contact affiliation	Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Parana, Brazil
contact email	lyris.godoy@fiocruz.br
lab head
Rafael de Almeida
contact affiliation	Fiocruz
contact email	alosteria@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD064463

PRIDE project URI

• PRIDE
  1. PXD064463
     1. Label: PRIDE project
     2. Name: Histone post-translational modifications of Leishmania braziliensis