PXD064039

PXD064039 is an original dataset announced via ProteomeXchange.

Title	Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging related phenotypes in mice and macaques
Description	Antler blastema progenitor cell (ABPC) is a novel type of skeletal mesenchymal stem cell with strong stemness and renewal ability. Here, we discovered that ABPC-derived extracellular vesicles (EVsABPCs) exerted strong geroprotective effect on aging tissues in aged mice and rhesus macaques (Macaca mulattas). We identified a variety of rejuvenating molecules in EVsABPCs that differed from those in EVs derived from rat bone marrow stromal stem cells (EVsBMSCs). In vitro, EVsABPCs rejuvenated senescent BMSCs and shifted their molecular signature towards a youthful state. In vivo, EVsABPCs increased femoral bone mineral density in mice and rhesus macaques by 2.5-fold and 1.5-fold, respectively. Besides, intravenous EVsABPCs significantly outperformed fetal-EVsBMSCs in improving physical performance, enhancing cognitive function, reducing systemic inflammation, and preserving major tissues in elderly mice. Notably, the aging clock highlights a roughly 3.54-months regression in overall aging in mice. Additionally, EVsABPCs showed similar geroprotective effects in elderly rhesus macaques, markedly improving locomotor performance and mitigating cortical volume atrophy. Conclusively, these findings suggest that the ABPC is a novel and practical source of EVs containing systemic rejuvenating factors and has considerable translational value for anti-aging interventions, particularly the rescue of aging bone.
HostingRepository	iProX
AnnounceDate	2025-05-18
AnnouncementXML	Submission_2025-05-18_23:09:43.280.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jinghui Huang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-18 23:09:29	ID requested
⏵ 1	2025-05-18 23:09:43	announced

Dataset with its publication pending

submitter keyword: Extracellular vesicles

Jinghui Huang
contact affiliation	Fourth Military Medical University
contact email	977816645@qq.com
lab head
Jinghui Huang
contact affiliation	Fourth Military Medical University
contact email	977816645@qq.com
dataset submitter

iProX dataset URI