PXD063955

PXD063955 is an original dataset announced via ProteomeXchange.

Title	Host sensing of microbially produced imidazole propionate is a driver and therapeutic 1 target in atherosclerosis
Description	Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs). Its prevention is based on the detection and treatment of traditional cardiovascular risk factors1 but often fails to identify individuals at risk for early vascular disease2. Recent research has suggested new players in the pathophysiology of atherosclerosis3, highlighting the need for alternative disease biomarkers and therapeutic targets to improve early diagnosis and therapy efficacy. Here, we identified that microbially produced imidazole propionate (ImP) is associated with the extent of atherosclerosis in mice and in two independent human cohorts. Furthermore, ImP administration to atherosclerosis-prone mice fed chow diet was sufficient to induce atherosclerosis without altering the lipid profile, and it was linked to activation of both systemic and local innate and adaptive immunity and inflammation. Specifically, we found that ImP caused atherosclerosis through Imidazoline-1 receptor (I1R) expressed in myeloid cells. Blocking this ImP/I1R axis inhibited the development of atherosclerosis induced by ImP as well as by high cholesterol diet in mice. Identification of the strong association of ImP with active atherosclerosis, along with the discovery of the contribution of the ImP/I1R axis to disease progression opens new avenues for improving the early diagnosis and personalized therapy of atherosclerosis.
HostingRepository	PRIDE
AnnounceDate	2025-09-15
AnnouncementXML	Submission_2025-09-14_18:38:20.725.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan A Lopez
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-05-15 00:09:03	ID requested
⏵ 1	2025-09-14 18:38:21	announced

10.1038/s41586-025-09263-w;

Mastrangelo A, Robles-Vera I, Ma, ñ, anes D, Gal, á, n M, Femen, í, a-Mui, ñ, a M, Redondo-Urzainqui A, Barrero-Rodr, í, guez R, Papaioannou E, Amores-Iniesta J, Devesa A, Lobo-Gonz, á, lez M, Carreras A, Beck KR, Ivarsson S, Gummesson A, Georgiopoulos G, Rodrigo-Tapias M, Mart, í, nez-Cano S, Fern, á, ndez-L, ó, pez I, Nu, ñ, ez V, Ferrarini A, Inohara N, Stamatelopoulos K, Bengur, í, a A, Cibrian D, S, á, nchez-Madrid F, Alonso-Herranz V, Dopazo A, Barbas C, V, á, zquez J, L, ó, pez JA, Gonz, á, lez-Mart, í, n A, Nu, ñ, ez G, Stellos K, Bergstr, ö, m G, B, ä, ckhed F, Fuster V, Iba, ñ, ez B, Sancho D, Imidazole propionate is a driver and therapeutic target in atherosclerosis. Nature, 645(8079):254-261(2025) [pubmed]

submitter keyword: atherosclerosis, human, imidazole propionate, microbiota

Juan A Lopez
contact affiliation	Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares CNIC Madrid Spain
contact email	jalopez@cnic.es
lab head
Juan A Lopez
contact affiliation	CNIC
contact email	jalopez@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD063955

PRIDE project URI

• PRIDE
  1. PXD063955
     1. Label: PRIDE project
     2. Name: Host sensing of microbially produced imidazole propionate is a driver and therapeutic 1 target in atherosclerosis