PXD063659 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Protein Disulfide Isomerase Coordinates Redox Homeostasis and ER Calcium Regulation for Optimal Lytic Cycle Progression in Toxoplasma gondii. SERCA-HA DVSF HA-IP LC-MS/MS |
| Description | The endoplasmic reticulum (ER) maintains an oxidative environment that promotes disulfide bond formation, a critical process for proper protein folding. Protein disulfide isomerases (PDIs) are ER resident enzymes that facilitate the formation, breakage, and rearrangement of disulfide bonds between cysteine residues, thereby stabilizing protein structures. Although PDIs are functionally diverse, they all contain at least 1 thioredoxin-like domain and mediate disulfide exchange through their conserved CXXC motifs. The Apicomplexan parasite, Toxoplasma gondii, infects approximately one third of the world population, posing a significant risk to immunosuppressed individuals and unborn fetuses. Its fast-replicating tachyzoite form engages in a lytic cycle, causing host tissue damage and contributing to pathogenesis. While approximately 26 PDIs are predicted to be present in T. gondii, their specific roles remain largely unexplored. In this study, we investigate TgPDIA3, a T. gondii PDI localized to the ER, along with several of its interacting protein substrates. We explore its role in ER redox activity and calcium sequestration and assess how these functions contribute to the parasite’s lytic cycle. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-31 |
| AnnouncementXML | Submission_2026-03-31_13:14:46.549.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Katherine Moen |
| SpeciesList | scientific name: Toxoplasma gondii GT1; NCBI TaxID: NEWT:507601; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-05-06 07:28:28 | ID requested | |
| ⏵ 1 | 2026-03-31 13:14:47 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LC-MS/MS, SERCA, DVSF |
Contact List
| Silvia Moreno |
|---|
| contact affiliation | Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, Moreno lab, University of Georgia, United States of America |
| contact email | smoreno@uga.edu |
| lab head | |
| Katherine Moen |
|---|
| contact affiliation | University of Georgia |
| contact email | katherine.moen26@uga.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063659
- Label: PRIDE project
- Name: A Protein Disulfide Isomerase Coordinates Redox Homeostasis and ER Calcium Regulation for Optimal Lytic Cycle Progression in Toxoplasma gondii. SERCA-HA DVSF HA-IP LC-MS/MS
