PXD062935 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 12 days |
| Description | One of the reproductive isolation mechanisms that restricts gene exchange and make speciation irreversible is sterility of inter(sub)specific hybrids. In the Prdm9-driven sterility of Mus m. musculus x Mus m. domesticus hybrids a Prdm9-interacting hybrid sterility gene was mapped in the X-linked Hstx2 locus. Here we show that the Mir465 microRNA gene cluster is the predicted Hstx2 hybrid sterility factor involved in Prdm9 interaction. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-06 |
| AnnouncementXML | Submission_2026-04-05_16:35:19.451.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lucie Pfeiferova |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-14 08:22:58 | ID requested | |
| ⏵ 1 | 2026-04-05 16:35:20 | announced | |
Publication List
| 10.1073/pnas.2510229122; |
| Jansa P, Tanieli G, Vucinic K, Lustyk D, Fusek K, Valiskova B, Morimoto K, Mizuno S, Ullrich K, Odenthal-Hesse L, Provaznik J, Benes V, Pfeiferova L, Kolar M, Gergelits V, Pialek J, Forejt J, -driven hybrid sterility in a copy number-dependent manner. Proc Natl Acad Sci U S A, 122(40):e2510229122(2025) [pubmed] |
Keyword List
| submitter keyword: MiR465, hybrid sterility,inbred mouse strain |
Contact List
| Jiri Forejt |
|---|
| contact affiliation | Laboratory of Mouse Molecular Genetics, Institute of Molecular Genetics, Czech Academy of Sciences Laboratory of Epigenetic Regulations, Institute of Molecular Genetics, Czech Academy of Sciences |
| contact email | jiri.forejt@img.cas.cz |
| lab head | |
| Lucie Pfeiferova |
|---|
| contact affiliation | Institute of Molecular Genetics of the Czech Academy of Sciences |
| contact email | lucie.pfeiferova@img.cas.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD062935 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062935
- Label: PRIDE project
- Name: Proteomics analysis of involvemnt of miRNA 465 in hybrid mouse sterility, 12 days
