Base on the classification of damp syndrome, we classified gastric precancerous lesions patients into distinct subtypes. In this cross-sectional investigation, we aim figure out the clinical feature difference between different subtypes. Furthermore, we conduct multi-omics analyses on blood samples to explore the microscopic biological feature of WD syndrome of gastric precancerous lesions. Our study aimed to illuminate the macroscopic and microscopic characteristics of WD syndrome in gastric precancerous lesions, which will provide a evidence for therapeutic strategies aimed at addressing WD syndrome of gastric precancerous lesions.