PXD061622

PXD061622 is an original dataset announced via ProteomeXchange.

Title	ClpXP, ClpCP and ClpEP proteases effects on the Streptococcus pneumoniae proteome
Description	In the important human pathogen, Streptococcus pneumoniae, the ClpP protease is essential for modulating virulence and the cellular stress response. Here, the Clp ATPase chaperones associate with the ClpP protease to mediate general and targeted proteolysis. To identify the ClpP-dependent function of the Clp ATPases, we modified the IGF-tripeptide ClpP recognition motif for each of the Clp ATPases. We assess the ClpP-dependent phenotypes associated with inactivation of each of the ClpEP (XCP), ClpCP (XEP) and ClpXP (CEP) proteases compared to the wild type (XCEP).
HostingRepository	PRIDE
AnnounceDate	2025-05-01
AnnouncementXML	Submission_2025-05-01_09:45:37.026.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Larissa Busch
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-09 18:04:10	ID requested
⏵ 1	2025-05-01 09:45:37	announced

Dataset with its publication pending

submitter keyword: ClpX, protein homeostasis, pneumococcus, ClpP, Streptococcus pneumoniae, ClpE, ClpC

Uwe Völker
contact affiliation	Department of Functional Genomics, University Medicine Greifswald
contact email	voelker@uni-greifswald.de
lab head
Larissa Busch
contact affiliation	Department of Functional Genomics, University Medicine Greifswald
contact email	larissa.busch@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD061622

PRIDE project URI

• PRIDE
  1. PXD061622
     1. Label: PRIDE project
     2. Name: ClpXP, ClpCP and ClpEP proteases effects on the Streptococcus pneumoniae proteome