PXD061570

PXD061570 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multi-omics analysis of thermogenic lipolysis in brown adipocytes
Description	The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are considered independently, offers novel insights into complex molecular interactions. Here, we present a multi-omics analysis of murine brown adipocytes undergoing thermogenic lipolysis, which is part of the non-shivering response to cold. Through combining information from multiple types of biomolecules, we describe what is important for each biochemical layer, and the system as a whole, at different time points. Furthermore, a classification of data integration approaches for multi-omics data analysis is presented.
HostingRepository	PRIDE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-21_17:35:20.103.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Holda Anagho-Mattanovich
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-07 01:18:12	ID requested
⏵ 1	2025-09-21 17:35:21	announced

Publication List

10.1016/j.isci.2025.113382;
Anagho-Mattanovich M, Anagho-Mattanovich HA, Argemi-Muntadas L, Nielsen ML, Gao Q, Moritz T, Multi-omics analysis of thermogenic lipolysis in brown adipocytes. iScience, 28(9):113382(2025) [pubmed]

10.1016/j.isci.2025.113382;

Anagho-Mattanovich M, Anagho-Mattanovich HA, Argemi-Muntadas L, Nielsen ML, Gao Q, Moritz T, Multi-omics analysis of thermogenic lipolysis in brown adipocytes. iScience, 28(9):113382(2025) [pubmed]

Keyword List

submitter keyword: transomics, brown adipocytes, lipolysis, proteomics, thermogenesis, metabolomics, LC-MS, GC-MS, transcriptomics,Multi-omics

submitter keyword: transomics, brown adipocytes, lipolysis, proteomics, thermogenesis, metabolomics, LC-MS, GC-MS, transcriptomics,Multi-omics

Contact List

Michael L. Nielsen
contact affiliation	Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen Current affiliation: Evosep Aps, Denmark
contact email	mln@evosep.com
lab head
Holda Anagho-Mattanovich
contact affiliation	Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
contact email	holda.anagho@cpr.ku.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD061570
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD061570

PRIDE project URI

Repository Record List

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