PXD061525

PXD061525 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Receptor kinase pathway signal tuning through a non-transcriptional incoherent feedforward loop
Description	This project investigated an auto-regulatory feedback in a plant receptor kinase pathway: The signaling of the endogenous CLAVATA3/EMBRYO SURROUNDING REGION 45 (CLE45) peptide via the receptor kinase BARELY ANY MERISTEM 3 (BAM3) in Arabidopsis (Arabidopsis thaliana) vascular development. Downstream, the plant-specific MEMBRANE-ASSOCIATED KINASE REGULATOR (MAKR) family protein MAKR5 conveys CLE45-BAM3 signaling, which is amplified by CLE45-BAM3-triggered enhancement of MAKR5 production through the stimulation of MAKR5 mRNA translation. At the same time, this signal amplification is dampened through CLE45-stimulated MAKR5 phosphorylation, which inactivates MAKR5, enhances its turnover and impinges on MAKR5 mRNA levels. In summary, the results suggest a non-transcriptional incoherent feedforward loop in which CLE45-BAM3 signaling is amplified via translation of MAKR5 mRNA yet also balanced via phosphorylation of MAKR5 protein.
HostingRepository	PRIDE
AnnounceDate	2025-05-28
AnnouncementXML	Submission_2025-05-28_01:17:50.671.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Hardtke
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-05 23:48:46	ID requested
⏵ 1	2025-05-28 01:17:51	announced

Publication List

Wang Q, Kang YH, Hardtke CS, Receptor kinase pathway signal tuning through a nontranscriptional incoherent feedforward loop. Proc Natl Acad Sci U S A, 122(16):e2420575122(2025) [pubmed]
10.1073/pnas.2420575122;

Wang Q, Kang YH, Hardtke CS, Receptor kinase pathway signal tuning through a nontranscriptional incoherent feedforward loop. Proc Natl Acad Sci U S A, 122(16):e2420575122(2025) [pubmed]

10.1073/pnas.2420575122;

Keyword List

submitter keyword: CLE45, receptor kinase, BAM3,Arabidopsis, MAKR5

submitter keyword: CLE45, receptor kinase, BAM3,Arabidopsis, MAKR5

Contact List

Christian Hardtke
contact affiliation	Department of Plant Molecular Biology, University of Lausanne, Biophore Building, DBMV, CH-1015 Lausanne, Switzerland
contact email	christian.hardtke@unil.ch
lab head
Christian Hardtke
contact affiliation	University of Lausanne
contact email	christian.hardtke@unil.ch
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD061525

PRIDE project URI

Repository Record List

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