Pseudomonas aeruginosa is an opportunistic bacterial pathogen that possesses a plethora of virulence factors, including the public goods siderophores and exoproteases. Mutants unable to produce either exoprotease or siderophores are selected in competition with producers; hence, these two virulence factors are prone to exploitation by social cheaters. However, so far most of the studies of exoprotease exploitation by social cheaters had been done in the reference strains PAO1 and PA14 and the information available of these behaviors in clinical or environmental isolates is limited to a few studies. In this work, we studied the exoproteases secreted by two clinical isolates from cystic fibrosis patients belonging to the epidemic clone ST274-CC274. We found that the exoprotease exploitation in these strains is mild and not a result of the selection of lasR mutants during continuous growth in casein as sole carbon source, in contrast with the paradigm in the reference strains.