PXD061236

PXD061236 is an original dataset announced via ProteomeXchange.

Title	Discovering nanoparticle corona ligands responsible for liver macrophage capture
Description	Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. It is well-known that serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here, we used a multi-omic strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors. We discovered six serum-adsorbed proteins for capture that bind to two liver macrophage receptors. Nanoparticle physico-chemical properties can affect the degree of the six serum proteins adsorbing to the surface, the probability of binding to cell receptors, and whether the liver removes them from circulation. We apply the identified adsorbed proteins to engineer decoy nanoparticles that prime the liver to take up fewer therapeutic nanoparticles, enabling more nanoparticles for targeting extrahepatic tissues. Elucidating the molecular interactions governing the nanoparticle journey in vivo will enable us to control nanoparticle delivery to diseased tissues.
HostingRepository	PRIDE
AnnounceDate	2025-05-18
AnnouncementXML	Submission_2025-05-18_11:32:11.657.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bram Bussin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-26 14:54:07	ID requested
⏵ 1	2025-05-18 11:32:12	announced

10.1038/S41565-025-01903-6;

submitter keyword: Corona,HUman, Serum, Mouse, Nanoparticle

Warren Chan
contact affiliation	University of Toronto
contact email	warren.chan@utoronto.ca
lab head
Bram Bussin
contact affiliation	University of Toronto
contact email	bram.bussin@utoronto.ca
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD061236
     1. Label: PRIDE project
     2. Name: Discovering nanoparticle corona ligands responsible for liver macrophage capture