PXD060056

PXD060056 is an original dataset announced via ProteomeXchange.

Title	Cholangiocarcinoma Cell of PDHA1 MS
Description	The discovery of various lysine acylations raises a question as to whether they are subject to dynamic regulation and, if so, by which enzymes. Since acyltransferases play a crucial role in the succinylation process (acyltransferases are responsible for coupling acyl-CoA to non-protein substrates, possibly aiding lysine acylation as a side reaction). Using immunoprecipitation (IP) and liquid chromatographytandem mass spectrometry (LC-MS/MS), we found the succinyltransferase DLST interacts with PDHA1 and had a succinylation effect.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:27:00.958.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ning Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-22 02:52:17	ID requested
⏵ 1	2025-05-07 06:27:01	announced

Zhang N, Sun L, Zhou S, Ji C, Cui T, Chu Q, Ye J, Liang S, Ma K, Liu Y, Li X, Guo X, Zhang W, Gu X, Cheng C, Zha Q, Tao S, Zhang Y, Chu J, Wu C, Zhang Y, Wang J, Liu Y, Liu L, Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation. Nat Commun, 16(1):3177(2025) [pubmed]

10.1038/s41467-025-58429-7;

submitter keyword: PDHA1, MS ,cholangiocarcinoma

Liu Lianxin
contact affiliation	1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. 2 Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, Anhui, 230001, China. 3 Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, Anhui, 230001, China.
contact email	liulx@ustc.edu.cn
lab head
Ning Zhang
contact affiliation	The First Affiliated Hospital of Harbin Medical University
contact email	zhangning6563@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD060056

PRIDE project URI

• PRIDE
  1. PXD060056
     1. Label: PRIDE project
     2. Name: Cholangiocarcinoma Cell of PDHA1 MS